Marisa Madrid obtained her PhD in Biology in 2007 (University of Murcia), funded by MECD with an FPU contract. For her postdoctoral training she joined Professor Iain Hagan Cell Division group (CRUK Manchester Institute) for 38 months, funded by EMBO with a Long-term Fellowship. In 2011 she obtained a “Juan de la Cierva” Fellowship and returned to the Microbial Physiology Group in the University of Murcia.

Her research line has been focused on understanding the functional connections established in the cell between critical signaling cascades in response to harsh environmental situations. Genomic and proteomic studies have improved the awareness of the complexity of the cellular signaling processes that classically have been analysed in a modular linear manner. Therefore, research oriented to decipher how these signaling routes crosstalk to generate specific adaptive responses that improve cellular survival is critical to many areas of Biology.

The PhD thesis of M. Madrid created a new research line in her group, the analysis of the regulation of the PKC-Cell Integrity pathway, in which excellent research results were obtained, including 3 first author papers, 10 papers as co-author and a book chapter. She performed a detailed study on the mechanisms of activation and deactivation of the SAPK and PKC-Cell Integrity cascades in response to stress, and how these two pathways interact with each other in order to generate an appropriate molecular response. Indeed, she described for the first time the existence of a molecular crosstalk between two MAPK pathways, which was awarded with the Fleming Award in 2008 (Spanish Society of Microbiology). These results were published in the Journal of Biochemical Chemistry (2004, 2006) and Molecular Biology of the Cell (2007). During her PhD period, she enjoyed two research internships in Prof. Jonathan Millar’s group in the National Institute for Medical Research (London) and Prof. Paul Nurse’s group in the Rockefeller University (New York).

During her postdoctoral period in Manchester she continued working in signaling but on cellular division control, trying to understand how intra- and extracellular signals are integrated at the spindle pole body to control entry into mitosis. In particular, she analyzed how Cut12, a spindle pole body component, is regulated by phosphorylation during mitosis. Parts of her results were presented in an invited conference and published in Current Biology (2013), showing that Cut12 phosphorylation on T75 and T78, which is dependent on CDK and NIMA kinase, blocks Cut12 association with PP1 positively enhancing mitotic commitment. In addition, Cut12 is phosphorylated in two additional essential sites critical for spindle activation (manuscript in preparation).

Since 2011, Dr. Madrid leads a research line focused on the interaction of the PKC-Cell Integrity pathway with other signaling cascades (TOR, PKA, HSP90) when cells are exposed to membrane or cell wall damaging compounds. In this period, she has published 3 papers as a first author (BMC Microbiology -2013-; Journal of Cell Science -2015-; Scientific Reports -2016-), 8 as a co-author and 1 as last author (Cellular Signalling, 2015). This research project has been funded by the Fundación Séneca (18976/JLI/13).

In the last years, she has been actively collaborating with international groups working in related areas such as those leaded by Rafael Carazo (University of Cambridge, paper under revision) and James Moseley (Dartmouth Medical School, Journal of Biological Chemistry 2015). Furthermore, M. Madrid is actively involved in the management and direction of research, by having supervised several PhD, Master, and undergraduate students.

For more details about my CV, please see the information below.

• Almansa-Gómez S, Prieto-Ruiz F, Cansado J, Madrid M. Autophagy modulation as a potential therapeutic strategy in osteosarcoma: current insights and future perspectives. International Journal of Molecular Sciences, 2023. https://doi.org/10.3390/ijms241813827. Impact Factor: 5.6

• Prieto-Ruiz F; Gómez-Gil E, Vicente-Soler J, Franco A, Soto T, Madrid M, Cansado J. Divergence of cytokinesis and dimorphism control by myosin II regulatory light chain in fission yeasts. iScience 2023, 26. https://doi.org/10.1016/j.isci.2023.107611. Impact Factor: 5.8

• Prieto-Ruiz F, Gómez-Gil E, Martín-García R, Pérez-Díaz AJ, Vicente-Soler J, Franco A, Soto T, Pérez P, Madrid M, Cansado J. Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism. eLife, 2023 . https://doi.org/10.7554/eLife.83285. Impact Factor: 7.7

• Pérez-Díaz AJ, Vázquez-Marín B, Vicente-Soler J, Prieto-Ruiz F, Soto T, Franco A, Cansado J, Madrid M. cAMP-Protein kinase A and stress-activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation. Autophagy, 2022. https://doi.org/10.1080/15548627.2022.2125204. Impact Factor: 13,391.

• Cansado J, Soto T, Franco A, Vicente-Soler J and Madrid M. The Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond. Journal of Fungi. 2021; 8(32). https://doi.org/10.3390/jof8010032. Impact Factor: 5,266.

• Vicente-Soler J, Soto T, Franco A, Cansado J, Madrid M. The Multiple Functions of Rho GTPases in Fission Yeasts. Cells. 2021; 10(6):1422. https://doi.org/10.3390/cells10061422. Impact Factor: 6,6

• Gómez-Gil E, Franco A, Vázquez-Marín B, Prieto-Ruiz F, Pérez-Díaz A, Vicente-Soler J, Madrid M, Soto T, Cansado J. Specific functional features of the Cell Integrity MAP kinase pathway in the dimorphic fission yeast Schizosaccharomyces japonicus. Journal of Fungi. 2021; 7(6):482. https://doi.org/10.3390/jof7060482. Impact Factor: 5,724

• Madrid M, Gómez-Gil E, Cansado J. Negative control of cytokinesis by stress-activated MAPK signaling. Current Genetics. 2021; 67(5):715-721. https://doi.org/10.1007/s00294-021-01155-6. Impact Factor: 2,695

• Gómez-Gil E, Martín-García R, Vicente-Soler J, Franco A, Vázquez-Marín B, Prieto-Ruiz F, Soto T, Pérez P, Madrid M, Cansado J. “Stress-activated MAPK signalling controls fission yeast actomyosin ring integrity by modulating formin For3 levels”. Elife (2020). https://doi.org/10.7554/eLife.57951. Impact factor: 8,140

• Prieto-Ruiz F, Vicente-Soler J, Franco A, Gómez-Gil E, Sánchez Marinas M, Vázquez-Marín B, Aligué R, Madrid M, Moreno S, Soto T, Cansado J.“RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.” mBio(2020). https://doi.org/10.1128/mBio.02815-19. Impact factor: 7,867

• Gómez-Gil E, Franco A, Madrid M, Vázquez-Marín B, Gacto M, Fernández-Breis J, Vicente-Soler J, Soto T, Cansado J.“Quorum sensing and stress-activated MAPK signaling repress yeast to hypha transition in the fission yeast Schizosaccharomyces japonicus.”. PLoS Genetics (2019). https://doi.org/10.1371/journal.pgen.1008192. Impact factor: 5,175

• Franco A, Soto T, Martín-García R, Madrid M,Vázquez-Marin B, Vicente-Soler J, Coll PM, Gacto M, Pérez P and Cansado J.“Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast”. Scientific Reports (2017).https://doi.org/10.1038/s41598-017-06053-x Impact factor: 4,122

• Madrid M, Vázquez-Marín B, Soto T, Franco A, Gómez-Gil E, Vicente-Soler J, Gacto M, Pérez P, Cansado J.“Differential functional regulation of PKC orthologs in fission yeast”. Journal of Biological Chemistry (2017).https://doi.org/10.1074/jbc.M117.786087. Impact Factor: 4,258

• Dodgson J, Chessel A, Vaggi F, Giordan M, Yamamoto M, Arai K, Madrid M, Geymonat M, Abenza JF, Cansado J, Sato M, Csikasz-Nagy A, Carazo Salas R.“Reconstructing regulatory pathways by systematically mapping protein localization interdependency networks”. BioRxiv (2017). https://doi.org/10.1101/116749

• Madrid M, Vázquez-Marin B, Franco A, Soto T, Vicente-Soler J, Gacto M and Cansado J. “Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast”. Scientific Reports (2016). https://doi.org/10.1038/srep37515. Impact Factor: 4,259

• Vázquez B, Soto T, Del Dedo JE, Franco A, Vicente J, Hidalgo E, Gacto M, Cansado J, Madrid M.“Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast”. Cell Signal (2015).https://doi.org/10.1016/j.cellsig.2015.09.017. Impact Factor: 4,315

• Kabeche R, Madrid M, Cansado J, Moseley JB. “Eisosomes regulate PI(4,5)P2 cortical clusters and MAP kinase signaling upon osmotic stress”. J Biol Chem (2015). https://doi.org/10.1074/jbc.M115.674192. Impact Factor: 4,573

• Madrid M, Jiménez R, Sánchez-Mir L, Soto T, Franco A, Vicente-Soler J, Gacto M, Pérez P and Cansado J. “Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast”. J Cell Sci (2015), 128(2):266-80. https://doi.org/10.1242/jcs.158295. Impact Factor: 5,325

• Sánchez-Mir L, Franco A, Martín-García R, Madrid M, Vicente J, Soto T, Gacto M, Pérez P, Cansado J. “Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity MAPK pathway.“ Mol. Cell. Biol. (2014), 34(14): 2745-2759. https://doi.org/10.1128/MCB.01515-13. Impact Factor:5,036

• Sánchez-Mir L, Soto T, Franco A, Madrid M, Viana R, Vicente J, Gacto M, Pérez P, Cansado J. “Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.” PLOS ONE (2014), 9(1):e88020. https://doi.org/10.1371/journal.pone.0088020. Impact factor: 3,534

• Sacristán-Reviriego A, Madrid M, Cansado J, Martín H, Molina M. “A conserved non-canonical docking mechanism regulates binding of dual specificity phosphatases to cell integrity MAPKs in budding and fission yeasts”. PLOS ONE (2014), 9(1):e85390. https://doi.org/10.1371/journal.pone.0085390. Impact Factor: 3,534

• Madrid M, Fernández-Zapata J, Sanchez-Mir L, Soto T, Franco A, Vicente-Soler J, Gacto M, Cansado J. Role of the fission yeast cell integrity MAPK pathway in response to glucose limitation. BMC Microbiol. (2013) Feb 11;13:34. https://doi.org/10.1186/1471-2180-13-34. Impact Factor: 2,976

• Grallert A, Chan KY, Alonso-Núñez M, Madrid M, Biswas A, Alvarez-Tabares I, Connolly Y, Tanaka K, Robertson A, Ortiz JM, Smith D, Hagan I. “Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe”. Curr Biol. (2013),23(3):213-22. https://doi.org/10.1016/j.cub.2012.12.039. Impact factor: 9,916

• Legaz-García MC, Miñarro-Giménez JA, Madrid M, Menárguez-Tortosa M, Torres-Martínez S, Fernández-Breis JT. “Linking Genome Annotation Projects with Genetic Disorders using Ontologies”. J Med Syst. 2012 Nov;36 Suppl 1:S11-23. https://doi.org/10.1007/s10916-012-9890-7. Impact Factor: 1,783

• Sanchez-Mir L, Franco A, Madrid M, Vicente-Soler J, Villar-Tajadura MA, Soto T, Perez P, Gacto M, Cansado J. “Biological significance of nuclear localization of MAPK Pmk1 in fission yeast“. Journal of Biological Chemistry (2012), 287(31):26038-51. https://doi.org/10.1074/jbc.M112.345611. Impact Factor: 4,651

• Miñarro-Gimenez JA, Egaña Aranguren M, Martínez Béjar R, Fernández-Breis JT, Madrid M. “Semantic integration of information about orthologs and diseases: the OGO system.”Journal of Biomedical Informatics (2011), 44(6):1020-31. https://doi.org/10.1016/j.jbi.2011.08.002. Impact Factor: 1,792

• Soto T, Villar-Tajadura MA, Madrid M, Vicente J, Gacto M, Pérez P, Cansado J. “Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GAP”. Journal of Biological Chemistry (2010), 285(15):11516-25. https://doi.org/10.1074/jbc.M109.071027. Impact Factor: 5,328

• Miñarro-Gimenez, J.A., Madrid, M., Fernandez-Breis, J.T. “OGO: an ontological approach for integrating knowledge about orthology”. BMC Bioinformatics (2009),10 Suppl 10:S13. https://doi.org/10.1186/1471-2105-10-S10-S13. Impact Factor: 3,428

• Núñez, A., Franco, A., Madrid, M., Soto, T., Vicente, J., Gacto, M., Cansado, J. “Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast”. Molecular Biology of the Cell (2009), 20(18):3996-4009. https://doi.org/10.1091/mbc.e09-05-0388. Impact Factor: 5,979

• Vicente-Soler, J., Soto, T., Madrid, M., Núñez, A., Cansado, J. and Gacto, M. Solubilization and characterization of a cell wall-bound trehalase from ascospores of the fission yeast Schizosaccharomyces pombe. Microbiological Research (2009), 164(3):304-11. https://doi.org/10.1016/j.micres.2006.12.005. Impact Factor: 1,771

• Villar-Tajadura, M.A., Coll, P.M., Madrid, M., Cansado, J., Santos, B., Pérez, P. “Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe”. Molecular Microbiology(2008), 70(4):867-81. https://doi.org/10.1111/j.1365-2958.2008.06447.x. Impact Factor: 5,213

• Barba, G., Soto, T., Madrid, M., Núñez, A., Vicente, J., Gacto, M., and Cansado, J. “Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast”. Cellular Signalling (2008), 20(4):748-57. https://doi.org/10.1016/j.cellsig.2007.12.017. Impact Factor: 4,305

• Madrid, M., Núñez, A., Soto, T., Vicente, J., Gacto, M and Cansado, J. “Stress-activated protein kinase-mediated down-regulation of the cell integrity pathway Mitogen-activated protein kinase Pmk1p by protein phosphatases”. Molecular Biology of the Cell (2007), 18(11):4405-19. https://doi.org/10.1091/mbc.e07-05-0484. Impact Factor: 6,028

• Soto, T., Núñez, A., Madrid, M., Vicente, J.,Gacto, M. and Cansado, J. “Transduction of centrifugation-induced gravity forces through mitogen- activated protein kinase pathways in the fission yeast Schizosaccharomyces pombe” Microbiology (2007), 153, 1519–1529.https://doi.org/10.1099/mic.0.2006/004283-0. Impact Factor: 3,110

• LaPeña, M.A., Vicente-Soler, J., Soto, T., Madrid, M., Núñez, A., Martínez, E., Cansado, J. and Gacto, M. Light- induced rhythmic changes in thermotolerance in stationary-phase cells of Candida utilis. International Microbiology (2006), 9(1): 61-4. PMID: 16636991. Impact Factor: 2,455

• Madrid, M., Soto, T., Khong, H.K., Franco, A., Vicente, J., Pérez, P., Gacto, M. and Cansado, J. Stress-induced response, localization and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. Journal of Biological Chemistry (2006), 281(4): 2033-43. https://doi.org/10.1074/jbc.M506467200. Impact Factor: 5,808

• Franco, A., Soto, T., Madrid, M., Vicente, J., Gacto, M. and Cansado, J. Functional characterization of Schizosaccharomyces pombe neutral trehalase altered in phosphorylatable serine residues. Archives of Microbiology (2005), 183(6): 394-400. https://doi.org/10.1007/s00203-005-0005-4. Impact Factor: 2,135

• Madrid, M., Soto, T., Franco, A., Paredes, V., Vicente, J., Hidalgo, E., Gacto, M. and Cansado, J. A cooperative role for Atf1p and Pap1 in the detoxification of the oxidative stress induced by glucose deprivation in Schizosaccharomyces pombe. Journal of Biological Chemistry (2004), 279(40): 41594-602. https://doi.org/10.1074/jbc.M405509200. Impact Factor: 6,355

• Paredes, V., Franco, A., Madrid, M., Soto, T., Vicente-Soler, J., Gacto, M. and Cansado, J. Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress. Yeast (2004), Vol. 21, No 7, p. 593-603. https://doi.org/10.1002/yea.1128. Impact Factor: 1,941

• Franco, A., Soto, T., Vicente-Soler, J., Paredes, V., Madrid, M., Gacto, M. and Cansado, J. A role for calcium in the regulation of neutral trehalase activity in the fission yeast Schizosaccharomyces pombe. Biochemical Journal (2003), Vol. 376, p. 209-217. https://doi.org/10.1042/BJ20030825. Impact Factor: 4,101

• Soto, T, Beltrán, F.F., Paredes, V, Madrid, M., Millar, J.B.A.,Vicente-Soler, J.,Cansado, J. and Gacto, M. Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe. European Journal of Biochemistry (2002), 269 1-10. https://doi.org/10.1046/j.1432-1033.2002.03214.x. Impact Factor: 2,999

• Franco A, Gacto M, Gómez-Gil E, Madrid M, Vicente-Soler J, Vázquez-Marín B, Cansado J, Soto T. (2021). Quorum Sensing: A Major Regulator of Fungal Development. In: Villa, T.G., de Miguel Bouzas, T. (eds) Developmental Biology in Prokaryotes and Lower Eukaryotes. ISBN:978-3-319-28366-1. Springer, Germany. https://doi.org/10.1007/978-3-030-77595-7_14.

• J. Vicente-Soler, M. Madrid, A. Franco, T. Soto, J. Cansado and M. Gacto. (2016). Quorum sensing as a target for antimicrobial therapy. In: New Weapons to Control Bacterial Growth, Chapter 7, p161-184. ISBN:978-3-319-28366-1. Springer, Germany. https://doi.org/10.1007/978-3-319-28368-5_8.

• M. Gacto, M. Madrid, A. Franco, T.Soto, J. Cansado, J. Vicente-Soler.(2014). The cornerstone of nucleic acid-affecting antibiotics in bacteria. In: Antimicrobial Compounds: Current Strategies and New Alternatives, Chapter 6, p149-175. ISBN:978-3-642-40443-6. Springer, Germany. https://doi.org/10.1007/978-3-642-40444-3_6.

• Gacto, M., Cansado, J., Vicente, J., Soto, T., and Madrid, M. Trehalose in yeast performance: facts and applications. In: Hots Spots in Applied Microbiology (2007), p51-71. pISSN:81-308-0144-2.

• Premio Fleming 2024 al trabajo “cAMP-Protein kinase A and stress-activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation” publicado en Autophagy (doi:10.1080/15548627.2022.2125204) en el año 2023.

• Premio Fleming 2008 al trabajo “Stress-activated protein kinase-mediated down-regulation of the cell integrity pathway mitogen-activated protein kinase Pmk1p by protein phosphatases” publicado en Molecular Biology of the Cell (doi:10.1091/mbc.e07-05-0484) en el año 2007.

• Prieto-Ruiz F, Gómez-Gil E, Martín-García R, Perez-Díaz A, León Zaragoza S, Vicente-Soler J, Franco A, Soto T, Pérez P, Cansado J, Madrid M.”Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism“.11th International Fission Yeast Meeting. 2023. Hiroshima (Japan).

• Pérez-Díaz A, León-Zaragoza S, Vicente-Soler J, Prieto-Ruiz F, Soto T, Franco A, Cansado J, Madrid M.”cAMP-Protein Kinase A and Stress-Activated MAP kinase signaling mediate transcriptional control of autophagy in fission yeast during glucose limitation or starvation“.11th International Fission Yeast Meeting. 2023. Hiroshima (Japan).

• Pérez-Díaz A, Vázquez-Marín B, Vicente-Soler J, Prieto-Ruiz F, Soto T, Franco A, Cansado J, Madrid M.”cAMP-Protein kinase A and Stress-Activated MAP kinase signaling mediate transcriptional control of autophagy during glucose limitation or starvation“. SEFAGIA 2022. Toledo (Spain).

• Ma W, Madrid M, Chan K.W., Connolly Y, Smith D, Hagan I.M.”Looping the Loop: reinforcing mitotic control through SPB recruitment of Cut12“.10th International Fission Yeast Meeting. 2019. Barcelona (Spain).

• Gómez-Gil E, Madrid M, Franco A, Prieto F, Vázquez-Marín B, Vicente-Soler J, Soto T, Cansado J.”Quorum sensing repress yeast to hypha transition in the fission yeast Schizosaccharomyces japonicus“.10th International Fission Yeast Meeting. 2019. Barcelona (Spain).

• Prieto F, Gómez-Gil E, Madrid M, Vázquez-Marín B, Pérez A, Vicente-Soler J, Soto T, Cansado J, Franco A.”Stress-activated MAPK signalling targeting of RNA-binding proteins in S. pombe“.10th International Fission Yeast Meeting. 2019. Barcelona (Spain).

• Vázquez-Marín B, Soto T, Martín-García R, Madrid M, Gómez-Gil E, Vicente-Soler J, Gacto M, Pérez P, Cansado J, and Franco A. ”Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast”. Póster. 7th Congress of European Microbiologists. 2017. Valencia (Spain).

• Vázquez-Marín B, Madrid M, Franco A, Soto T, Gómez-Gil E, Vicente-Soler J, Gacto M, and Cansado J. ”Multiple crosstalks between tor and the Cell Integrity MAPK signalling pathway in fission yeast”. Póster. 7th Congress of European Microbiologists. 2017. Valencia (Spain).

• Gómez-Gil E, Vázquez-Marín B, Soto T, Franco A, Vicente-Soler J, Gacto M, Pérez P, Cansado J, and Madrid M. ”Differential regulation of activation and stabilization of PKC orthologs in fission yeast”. Póster. 7th Congress of European Microbiologists. 2017. Valencia (Spain).

• Soto T, Gómez-Gil E, Vázquez-Marín B, Madrid M, Vicente-Soler J, Gacto M, Cansado J and Franco A. ”Characterization and functional analysis of Mitogen Activated Protein Kinases in the dimorphic fission yeast Schizosaccharomyces japonicus”. Póster. 7th Congress of European Microbiologists. 2017. Valencia (Spain).

• Carazo-Salas, RE., Graml, VM., Studera, XE., Lawson, J., Chessel, A., Dodgson, J., Vaggi, F., Geymonat, M., Wagstaff, L., Antal, B., Giordan, M., Bortfeld-Miller, M., Yamamoto, M., Arai, K., Abenza, J., Walter, T., Madrid, M., Cansado, J., Sato, M., Csikasz-Nagy, A., Piddini, E. ”Systematically discovering genes and pathways that control and link cellular processes using High Content Microscopy and Big Data approaches”. Conferencia plenaria.8th International Fission Yeast Meeting. 2015. Japan.

• Dodgson, J., Chessel, A., Vaggi, F., Giordan, M., Yamamoto, M., Arai, K., Madrid, M., Geymonat, M., Abenza, JF., Cansado, J., Sato, Masamitsu, S., Csikasz-Nagy, A., Carazo-Salas, RE.”Reconstructing cell polarity regulatory pathways by systematically mapping polarity factor localization interdependency networks”. Poster.8th International Fission Yeast Meeting. 2015. Japan.

• Sacristán-Reviriego, A., Madrid, M., Cansado, J., Martín, H., Molina, M.”A novel motif IYT present in dual specificity phosphatases mediates binding to Cell Wall Integrity MAPKs in yeasts”. Poster. 26th International Conference on Yeast Genetics and Molecular Biology. 2013. Germany.

• Kuan Yoow Chan, Agnes Grallert, Marisa Alonso-Núñez, Marisa Madrid, Ashapurno Biswas, Isabel Alvarez-Tabarés, Yvonne Connolly, Kayoko Tanaka, Alasdair Robertson, Iain M Hagan. “Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe”. Poster. 7th International Fission Yeast Meeting. 2013. London (UK).

• Madrid, M., Franco, A., Sánchez-Mir, L., Martin-García, R., Vicente-Soler, J., Soto, T., Gacto, M., Pérez, P., Cansado, J. “Role of palmitoylation in Rho2-dependent signaling in fission yeast”. Poster. 7th International Fission Yeast Meeting. 2013. London (UK).

• Madrid, M., Sánchez-Mir, L., Soto, T., Fernández-Zapata J., Franco, A., Vicente, J., Gacto, M., Cansado, J.”Phosphoinositide-dependent protein kinase-1 (PDK1) ortholog Ksg1 regulates cell integrity MAPK pathway in the fission yeast Schizosaccharomyces pombe”. Poster. 22nd IUBMB and 37th FEBS Congress. 2012. Sevilla (Spain).

• Franco-Sánchez, A., Sánchez-Mir, L., Madrid-Mateo, M., Soto-Pino, T., Vicente-Soler, J., Martín-García, R., Gacto, M., Pérez, P., Cansado, J. “Role of palmitoylation in cell integrity MAPK signaling in fission yeast”. Poster. BS Meeting on Regulation of protein trafficking and function by palmitoylation. 2012. Oxford (UK).

• M. Madrid, A. Patel, Y Connolly, D. Smith and I. Hagan. “Cdc2 and Plo1 cooperatively phosphorylate and activate Cut12 to promote mitotic entry and bipolar spindle formation from the spindle pole body”. Centrosomes and Spindle Pole Bodies EMBO Conference. 2-6 October 2011. Barcelona (Spain).

• Maria del Carmen Legaz Garcia, Jose Antonio Miñarro Giménez, Marisa Madrid, Santiago Torres Martinez and Jesualdo Tomás Fernández-Breis. “Using Ontologies for Supporting Genomic Sequence Annotation Project”. First International Workshop on Semantic Applied Technologies on Biomedical Informatics. August, 2011. Chicago (USA).

• Jesualdo Tomás Fernández Breis, Marisa Madrid, Jose Antonio Miñarro-Gimenez, Mari Carmen Legaz-Garcia, Mikel Egaña Aranguren, Robert Stevens. “Exploitation of Semantic Gene Ontology Annotations for Schizosaccharomyces pombe” The Sixth International Fission Yeast Meeting. 25-30 June 2011. Boston (USA).

• Madrid, M., Patel, A., Connolly, Y., Smith, D., Hagan, I. “Cdc2 and Plo1 cooperatively phosphorylate and activate Cut12 promoting mitotic entry and bipolar spindle formation from the spindle pole body”. The Sixth International Fission Yeast Meeting. 25-30 June 2011. Boston (USA).

• Madrid, M., Connolly, Y., Smith, D., Patel, A., Hagan, I. “Cdc2 and Plo1 cooperatively phosphorylate and activate Cut12 promoting mitotic entry and bipolar spindle formation from the spindle pole body”. EMBO Fellows Meeting 2011. 16-19 June 2011. Heidelberg (Germany).

• Madrid, M., Tanaka, K., Robertson, A., Connolly, Y., Smith, D., Hagan, I. “Cdc2 mediated phosphorylation on the spindle pole body protein Cut12 influences mitotic commitment in fission yeast”. BSCB meeting “Cell Organisation through the cell cycle”. 4-5 Septiembre, 2010. Oxford (Reino Unido).

• Madrid, M., Robertson, A., Tanaka, K., Hagan, I. “Phospho-regulation of the SPB mitotic regulator Cut12”. Poster. 5th International Fission Yeast Meeting. 26-31 Octubre, 2009. Tokyo (Japón).

• Nuñez, A., Franco-Sánchez, A., Madrid, M., Soto, T., Vicente, J., Gacto, M and Cansado, J. “A role for RACK-1 ortholog Cpc2 in the modulation of stress response in fission yeast”. III Congress of European Microbiologists. Gotheborg, Sweden, 2009.

• Franco Sanchez, A., Madrid, M., Núñez, A., Soto, T., Vicente, J., Gacto, M. and Cansado, J. Biological significance of nuclear targeting of Pmk1 MAPK in fission yeast. III Congress of European Microbiologists. Gotheborg, Sweden, 2009.

• Miñarro-GimenezJ.A.,Madrid,M.,Fernández-BreisJ.T.“Semantic integration and exploitation of orthology information and genetic disorders”. 2nd Workshop on semantic web applications and tools for life sciences. Amsterdam, 2009.

• Miñarro-Gimenez J.A., Madrid, M., Fernández-Breis J.T. “An integrated ontological knowledge base about orthologous genes and proteins”. Workshop on semantic web applications and tools for life sciences. Edimburgo, Reino Unido, 2008.

• Madrid, M., Soto, T., Vicente, J., Gacto, M. and Cansado, J. “Cross-talk between the stress activated protein kinase pathway and the cell integrity pathway in fission yeast”. Ponencia. Workshop: Cell wall and cell integrity, 14 de junio. Moderadores: Mohan Balasubramanian y Pilar Pérez. 4th International Fission Yeast Meeting. 11-16 junio, 2007. Copenhagen (Dinamarca).

• Soto, T., Núñez, A., Barba, G., Madrid, M., Vicente, J., Cansado, J. and Gacto, M. “Activation of Mitogen- Activated Protein Kinase pathways by enhanced gravity forces in the fission yeast schizosaccharomyces pombe”. Poster. 4th International Fission Yeast Meeting. 11-16 junio,2007. Copenhagen (Dinamarca).

• Madrid, M., Núñez, A., Barba, G., Soto, T., Vicente, J., Gacto, M. and Cansado, J. “Nuclear localization signal mediates subcellular targeting of MAPK Pmk1p in fission yeast”. Poster. 4th International Fission Yeast Meeting. 11- 16 junio,2007. Copenhagen (Dinamarca).

• Madrid, M., Soto, T., Núñez, A., Barba, G., Vicente, J., Gacto, M and Cansado, J. “Cross-talk between the stress activated protein kinase pathway and the cell integrity pathway in fission yeast”. Poster. 4th International Fission Yeast Meeting. 11-16 junio,2007. Copenhagen (Dinamarca).

• Madrid, M., Soto, T., Núñez, A., Vicente, J., Gacto, M. y Cansado, J. “Dual-specific phosphatase Pmp1 and the stress activated protein kinase-dependent tyrosin phosphatases Pyp1 and Pyp2 negatively modulate Pmk1 activation in Schizosaccharomyces pombe.” Ponencia. Workshop: Microbial responses to stress. Moderador: Francesc Posas. 2nd FEMS Congress of European Microbiologists. Madrid, 2006.

• Sánchez M, Pérez-Díaz A, Prieto F, León S, Marín A, Cano L, Núñez A, Vicente J, Franco A, Soto T, Cansado J, Madrid M. Factores inductores de la autofagia y relevancia de la ruta AMPc-PKA en la levadura dimórfica Schizosaccharomyces japonicus. Póster. XVII Congreso Nacional de Biotecnología. Murcia, 2024.

• Marín Castillo A, Prieto-Ruiz F, León Zaragoza S, Sánchez-Giménez M, Cano Ríos L, Núñez A, Vicente J, Franco A, Soto T, Madrid M, Cansado J. Papel de la ruta AMPc-PKA durante la regulación de la integridad del citoesqueleto de actina y la citocinesis en Schizosaccharomyces pombe. Póster. XVII Congreso Nacional de Biotecnología. Murcia, 2024.

• Pérez-Díaz A, Vázquez-Marín B, Vicente-Soler J, Franco A, Cansado J, Madrid M. La señalización de la ruta AMPc-PKA y de la ruta de MAP quinasas de respuesta a estrés median el control transcripcional de la autofagia en Schizosaccharomyces pombe durante la limitación de glucosa. Póster. XV Congreso Nacional de Micología. Valencia, 2022.

• Prieto-Ruiz F, Gómez-Gil E, Martín-García R, Pérez-Díaz A, López R, Grao D, Vicente-Soler J, Franco A, Soto T, Pérez P, Madrid M, Cansado J. Papel de las p21 quinasas en el control de la citocinesis en respuesta a cambios en el metabolismo de la fuente de carbono en S. pombe. Ponencia. XV Congreso Nacional de Micología. Valencia, 2022.

• López R, Vázquez-Marín B, Cansado J, Madrid M. Interacción funcional entre la Rho GTPasa Cdc42 y las proteínas quinasas C y la ruta de MAPK de integridad celular en la levadura Schizosaccharomyces pombe. Póster. XV Congreso Anual de Biotecnología BAC 2022. Valencia, 2022.

• Gómez Gil E, Franco A, Vázquez-Marín B , Prieto-Ruiz F, Pérez-Díaz A, Vicente-Soler J, Madrid M, Cansado J. Caracterización funcional de la ruta de MAP quinasas de integridad celular (CIP) en la levadura dimórfila Schizosaccharomyces japonicus. Ponencia. XXVIII Congreso Nacional de Microbiología, 2021.

• Pérez A, Vázquez B, Prieto F, Gómez-Gil E, Soto T, Franco A, Vicente-Soler J, Cansado J, Madrid M. Relación de la autofagia en respuesta al déficit de glucosa en Schizosaccharomyces pombe. Póster. XXVIII Congreso Nacional de Microbiología, 2021.

• Prieto-Ruiz F, Pérez-Diaz A, Vázquez-Marin B, Gómez-Gil E, Vicente-Soler A, Soto T, Cansado J, Madrid M. Relación entre la autofagia y la integridad del citoesqueleto de actina y microtúbulos en Schizosaccharomyces pombe. Póster. XXVIII Congreso Nacional de Microbiología, 2021.

• Soto T., Prieto F., Madrid M., Vicente-Soler J., Gómez-Gil E., Vázquez-Marín B., Franco A., y J. Cansado. Regulación de rutas de MAP quinasas por proteínas de unión a RNA en Schizosaccharomyces pombe. Ponencia. XIV Congreso Nacional de Micología. Tarragona, 2018

• Gómez-Gil E., Franco A., Vicente-Soler J., Madrid M., Prieto F., Vázquez-Marín B., Cansado, J., y T. Soto. Caracterización funcional de rutas de MAP quinasas en Schizosaccharomyces japonicus y su papel durante la transición levadura-hifa. Ponencia. XIV Congreso Nacional de Micología. Tarragona, 2018

• Madrid, M., Vázquez-Marín, Beatriz., Franco Sánchez, A., Soto, T., Gómez-Gil, Elisa., Vicente-Soler, J., Gacto Fernández, M., Cansado, J. Interacción funcional entre la ruta de MAP quinasas de integridad celular y TORC2 en Schizosaccharomyces pombe. 13 Congreso Nacional de Micología. Lleida, 2016

• Soto Pino T., Vicente Soler J., Madrid, M., Franco Sánchez, A., Cansado Vizoso J., Gacto Fernández, M. Diseño de un banco de preguntas de respuesta múltiple y su aplicación al aprendizaje de Microbiología general en el grado en Biología. II Reunión de Docencia y Difusión de la Microbiología. Alicante, 2014

• Soto Pino T., Vicente Soler J., Madrid, M., Franco Sánchez, A., Cansado Vizoso J., Gacto Fernández, M. Desarrollo de una actividad continua en el aprendizaje de la Microbiología. I Reunión de Docencia y Difusión de la Microbiología. Madrid, 2012

• Madrid, M., Cansado, J., Connolly, Y., Smith, D., Hagan, I. Las quinasas mitóticas Cdc2 y Plo1 fosforilan a la proteina del corpúsculo polar del huso Cut12 de manera secuencial, promoviendo el inicio de la mitosis y la formación del huso mitótico en la levadura Schizosaccharomyces pombe. XXXVIII Congreso de la Sociedad Española de Genética. Murcia, 2011.

• Cansado Vizoso J., Gacto Fernandez M.J., Soto Pino T., Vicente Soler J., Núñez Hernández A., Madrid M. Múltiples modos de regulación de la ruta de MAP quinasas de integridad celular en Schizosaccharomyces pombe. XX Congreso Nacional de Micología, Sevilla, 2010.

• Soto, T., Barba, G., Núñez, A., Madrid, M., Franco, A., Vicente- Soler, J, Gacto, M., Cansado, J. “La activación del módulo de MAP quinasas de integridad celular en Schizosaccharomyces pombe es regulada por múltiples rutas de señalización”. Poster. XIX Congreso Nacional de Micología, Córdoba, 2008.

• Núñez, A., Soto, T., Madrid, M., Franco, A., Vicente-Soler, J., Gacto, M., Cansado, J. “La proteína adaptadora Cpc2 regula el ciclo celular y la respuesta a estrés en S. pombe”. Poster. XIX Congreso Nacional de Micología, Córdoba, 2008.

• Núñez, A., Madrid, M., Barba, G., Soto, T., Vicente, J., Gacto, M., y Cansado, J. “Cpc2p, un ortólogo de RACK1 en células superiores, modula la respuesta frente a estrés en Schizosaccharomyces pombe”. Poster. XXI Congreso Nacional de Microbiología. Sevilla, 2007.

• Madrid, M., Cansado, J. y Gacto, M. “Dianas celulares y mecanismos de control del crecimiento regulados por la MAPK Pmk1 en Schizosaccharomyces pombe”. Caracterización de los circuitos moleculares que definen su activación.” Ponencia. Aula de Medicina. Campus de Excelencia. Fuerteventura, 2006.

• Madrid, M., Soto, T., Khong, K., Franco, A., Vicente, J., Pérez, P., Gacto, M. y Cansado, J. “Activación, localización y regulación de la MAP kinasa Pmk1 en Schizosaccharomyces pombe”. Poster. XX Congreso Nacional de Microbiología. Cáceres, 2005.

• M. Gacto, M. Madrid, T. Soto, J. Vicente-Soler, M. Morente, H.K: Khong y J. Cansado. “Inducción de estrés oxidativo por ausencia de glucosa: papel detoxificante de los factores de transcripción Atf1p y Pap1 en Schizosaccharomyces pombe”. Ponencia. Simposio: Genética y biología molecular de hongos. VII Congreso Nacional de Micología. Salamanca, 2004.

• J. Cansado, A. Franco, J. Vicente-Soler, T. Soto, M. Madrid, V. Paredes y M. Gacto. “Papel del calcio en la regulación de la actividad trehalasa neutra en la levadura Schizosaccharomyces pombe”. Poster. XIX Congreso Nacional de Microbiología. Santiago de Compostela, 2003.

• T. Soto, M. Madrid, V. Paredes, A. Franco, J. Vicente-Soler, M. Gacto y J. Cansado. “Efecto de la actividad de la proteína kinasa dependiente de AMPc sobre la ruta SAPK de Schizosaccharomyces pombe”. Poster. XIX Congreso Nacional de Microbiología. Santiago de Compostela, 2003.

• V. Paredes, A. Franco, M. Madrid, T. Soto, J. Vicente-Soler, M. Gacto y J. Cansado. “La ruta de proteínas kinasas activable por estrés ejerce un control sobre la regulación del metabolismo de la trehalosa en Schizosaccharomyces pombe a nivel transcripcional y post-traduccional”. Poster. XIX Congreso Nacional de Microbiología. Santiago de Compostela, 2003.

• M. Madrid, T. Soto, V. Paredes, J. Vicente-Soler, A. Franco, J. Cansado y M. Gacto. “Activación de la ruta SAPK de Schizosaccharomyces pombe durante la transición fermentación-respiración”. Poster. XIX Congreso Nacional de Microbiología. Santiago de Compostela, 2003.