Research

Research group:

-E026-02 Medical Microbiology (University of Murcia). https://curie.um.es/curie/catalogo-ficha.du?seof_codigo=1&perf_codigo=4&cods=E026*02

-IMIB, Área 6, Línea 3. http://www.imib.es/portal/investigacion/linea.jsf?id=29

ORCIDhttp://orcid.org/0000-0003-1014-0595

Research interest:

-Lipidomic: structure and biological activity of the cell envelope lipids of mycobacteria and other bacteria (trehalose dimycolate -cord factor-, mycolic acids, phospholipids, glycolipids).

-Cell wall bacterial lipids and antibiotic resistance.

Recent research project:

-‘Estructura y actividad biológica de cord factor de Mycobacterium habana TMC 5135, cepa inmunogénica en tuberculosis y lepra experimentales’. Ministerio de Ciencia e Investigación, Instituto de Salud Carlos III, Spain. 2009-2011.

-'Unravelling in utero determinants predicting lung infection in infants: a step for prenatal prevention of asthma', PIE 15/00051 (2016-2018), Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, Spain. IMIB Research groug 5.

Some publications:

-Ether-linked lipids of Dermabacter hominis, a human skin actinobacterium. Valero-Guillén PL, Fernández-Natal I, Marrodán-Ciordia, T, Soriano F, Tausch A. Chem Phys Lipids. 2016, 196: 24-32.

-Cord factors from atypical mycobacteria (Mycobacterium alvei, Mycobacterium brumae) stimulate the secretion of some pro-inflammatory cytokines of relevance in tuberculosis. Linares C, Bernabéu A, Luquin M, Valero-Guillén PL. Microbiology. 2012 Nov;158(Pt 11):2878-85. doi: 10.1099/mic.0.060681-0. PMID: 22977091 Free Article.

-Nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice. Trevino-Villarreal JH, Vera-Cabrera L, Valero-Guillén PL, Salinas-Carmona MC. Infect Immun. 2012 Oct;80(10):3587-601. doi: 10.1128/IAI.00446-12. PMID: 22851755 Free PMC Article.

-Structural studies of cord factors from Mycobacterium simiae related to the capacity for tumour necrosis factor alpha (α-TNF) induction. Mederos LM, Montoro EH, Bernabéu A, Linares C, Valero-Guillén PL. Microbiology. 2010 Dec;156(Pt 12):3744-53. doi: 10.1099/mic.0.042077-0. PMID: 20688816 Free Article.

-Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids. Rafidinarivo E, Lanéelle MA, Montrozier H, Valero-Guillén P, Astola J, Luquin M, Promé JC, Daffé M. J Lipid Res. 2009 Mar;50(3):477-90. doi: 10.1194/jlr.M800384-JLR200. PMID: 18772482 Free Article.

ResearchID

-https://www.researcherid.com/workSpacePublications.action

PubMed:

-http://www.ncbi.nlm.nih.gov/pubmed/?term=valero-guillen

Google Scholar:

-https://scholar.google.es/scholar?q=valero-guillen&btnG=&hl=es&as_sdt=0%2C5

-https://scholar.google.es/citations?user=ZxiXHHgAAAAJ&hl=es

International research participation: (2009-2012)

-Dr. M. Daffé, Intitut of Pharmacology and Structural Biology-CNRS, Toulouse, France. http://www.ipbs.fr/?-Mycobacterial-envelopes-structure-&lang=en

-Dr. M.C. Carmona-Salinas. Departamento de Inmunología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Méjico. http://www.uanl.mx/universidad/persona/administrativo/mario-cesar-salinas-carmona.html

Recent PhD thesis:

-Dr. C. Linares, University of Murcia, Spain, 2013.‘Estructura del cord factor de micobacterias atípicas y su relación con la inducción de diversas citoquinas de relevancia en tuberculosis’.

Research in progress:

-Distribution of mycolic acids in the cell envelope of mycobacteria.

-Lipids of Dermabacter hominis and daptomycin resistance.

-Bacterial fatty acids in saliva and dental plaque of patients with different dental orthodontic materials.

-From lipidomic to microbiome.